Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefditoren pivoxil (ME 1207) 是一种半合成、广谱、β-内酰胺酶耐药的第三代头孢菌素抗生素,具有杀菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 157 | 现货 | ||
5 mg | ¥ 323 | 现货 | ||
10 mg | ¥ 583 | 现货 | ||
25 mg | ¥ 1,030 | 现货 | ||
50 mg | ¥ 1,630 | 现货 | ||
100 mg | ¥ 2,830 | 现货 | ||
200 mg | ¥ 4,200 | 现货 | ||
500 mg | ¥ 6,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 583 | 现货 |
产品描述 | Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. |
体外活性 | Cefditoren has MIC50/MIC90 results for Moraxella catarrhalis and Haemophilus influenzae of 0.12/0.5 and < or = 0.008/0.015 mg/mL, respectively. [1] Cefditoren (MIC(90), 0.5 mg/mL) is 4- to 128-fold more active than comparison beta-lactams against the pneumoococci and was the most potent beta-lactam (including penicillin) versus beta-haemolytic streptococci. Cefditoren (MIC(90) in mg/mL/% susceptible) activity against all tested H. influenzae (0.03/100) and M. catarrhalis (0.06-0.5/100) is comparable to Cefixime and significantly greater than cefaclor. Cefditoren pharmacokinetics demonstrate a T(1/2) of 1.5-2 hours and C(max) values of 2.8 and 4.6 mg/mL, respectively with 200 or 400 mg doses of Cefditoren pivoxil. [2] Cefditoren possesses a broad-spectrum of cidal antibacterial activity against both Gram-positive and Gram-negative species with stability to many beta-lactamases of clinical importance. [3] Cefditoren is also effective against methicillin-susceptible strains of Staphylococcus aureus. Cefditoren has compared favorably against other orally administered antibiotics used against the most commonly isolated respiratory tract pathogens. [4] Cefditoren up-regulates the expression levels of Mrp2, Bcrp and Oat2, and down-regulate P-gp and Oct1 mRNA expression. [5] |
别名 | 头孢妥仑匹酯, ME 1207, Cefditoren pivaloyloxymethyl ester, Cefditoren pivoxyl |
分子量 | 620.72 |
分子式 | C25H28N6O7S3 |
CAS No. | 117467-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 45 mg/mL (72.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.611 mL | 8.0552 mL | 16.1103 mL | 40.2758 mL |
5 mM | 0.3222 mL | 1.611 mL | 3.2221 mL | 8.0552 mL | |
10 mM | 0.1611 mL | 0.8055 mL | 1.611 mL | 4.0276 mL | |
20 mM | 0.0806 mL | 0.4028 mL | 0.8055 mL | 2.0138 mL | |
50 mM | 0.0322 mL | 0.1611 mL | 0.3222 mL | 0.8055 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cefditoren pivoxil 117467-28-4 Microbiology/Virology Antibiotic Antibacterial 头孢妥仑匹酯 ME 1207 Cefditoren pivaloyloxymethyl ester Cefditoren pivoxyl ME-1207 ME1207 Inhibitor inhibitor inhibit